Inferring the Forces Controlling Metaphase Kinetochore Oscillations by Reverse Engineering System Dynamics
Fig 3
Determination of oscillatory trajectories using three quality statistics.
(A) Histogram of explained variance (EV) of each trajectory. (B) Explained variance of each trajectory arranged by cell. (C) Histogram of log Bayes factor of the kinetochore model Mcoh against Brownian motion MBM (log B[Mcoh/MBM]) of each trajectory. (D) log B[Mcoh/MBM] of each trajectory arranged by cell. (E) Histogram of directional correlation statistic DΔt of each trajectory. (F) DΔt of each trajectory arranged by cell. (G) log B[Mcoh/MBM] plotted against EV for each trajectory. Trajectories are coloured according to DΔt; blue have significant directional correlations. (H) Mean trajectory positions within the metaphase plate viewed along the spindle axis (Y, Z) coloured by EV. All converged trajectories are shown in panels (A-G) (n = 1169); only those from grey area in (G) are shown in (H) (n = 843).