Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments
Fig 4
The duration of the G1 phase is particularly sensitive to changes in parameters.
(A) Comparison of sensitivities of TG1 and TS/G2/M to changes in parameters in constant conditions. The strict proportional relationship is clear in all cases. (B) Examples of monotonic changes in TG1 down generations. (C) Examples of nonmonotonic changes in TG1 down generations. (D) Comparison of fractions of parameters exhibiting monotonic and nonmonotonic changes in TG1 for all three models (see S1 Text for details of calculation).