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Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments
Fig 3
Example dynamic sensitivity analysis of the mitotic cyclin synthesis parameter in the Barik model (ks,bM).
(A) 
and 
for all parameters in the Barik model, with the parameter representing mitotic cyclin synthesis marked in green. (B) Sensitivity of Vdau and TS/G2/M for four generations following a step-change in parameters applied at 30mins. (C) As in (B), for a step-change in parameters applied at 104mins. (D) 
and 
down generations as functions of time. Points from (B,C) are marked by blue and red circles, respectively. Vertical dashed lines represent the time of the G1-S transition.
doi: https://doi.org/10.1371/journal.pcbi.1004604.g003