Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments
Fig 1
Overview of cell cycle dynamics in changing environments.
(A) Schematic of environmental control of the cell cycle, involving direct regulation through signalling pathways and indirect effects through growth. (B) Cell cycle progression and growth. Cells grow isotropically for the duration of G1 (TG1), before polarising growth to a bud for the remainder of the cell cycle (TS/G2/M). The daughter cell size is determined by the bud size at division. (C) Simulation of cell cycle dynamics in the Barik model. Cell volume grows exponentially, while cell cycle components such as the G1 and mitotic cyclins oscillate. Budding occurs when G1 cyclins increase through a threshold, while mitosis occurs when mitotic cyclins decrease through a threshold.