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Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion

Fig 9

Calcium currents.

A: Comparison of HVA Ca²⁺ current (I_CaHVA) activation function between GLUTag (solid line) and primary L-cells (dotted line), superimposed T-type Ca²⁺ current activation function (dot-dashed line). B: Comparison of HVA Ca²⁺ current (I_CaHVA) inactivation function between GLUTag (solid line) and primary L-cells (dotted line), superimposed T-type Ca²⁺ current inactivation function (dot-dashed line). C: Comparison of HVA Ca²⁺ current (I_{CaHV A}) -V relationship between GLUTag (solid line) and primary L-cells (dotted line), superimposed T-type Ca²⁺ current activation function (dot-dashed line) and the total Ca²⁺ current (dashed line) in primary L-cells.

doi: https://doi.org/10.1371/journal.pcbi.1004600.g009