Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
Fig 7
Simulation of application of Ca+-channel blocker.
A: Simulation of application of the L-type Ca2+-channel blocker, nifedipine, in GLUTag cells, with default parameter except GSGLT1 = 10 mM, gK(ATP) = 0.015 nS/pF. The average Ca2+ current is indicated in red (right axis). B: Simulation of application of partial block of HVA Ca2+-channels in primary L-cells, with default parameters except GSGLT1 = 10 mM. The average Ca2+ currents are in both panels indicated in red (right axes). Grey bars indicate Ca2+-channel blocker application.