Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
Fig 6
Simulation of application of Na+-channel blocker TTX.
A: Simulation of glucose-induced electrical activity (GSGLT1 = 10 mM and gK(ATP) = 0.015 nS/pF) and subsequent application of TTX in GLUTag cells with default parameters. Red line represents mean voltage during electrical activity. B: Calcium current corresponding to the simulation in panel A. Red line represents mean Ca2+ current during electrical activity. C: Simulation of current-induced electrical activity (Iapp = 0.1 pA/pF, GSGLT1 = 1 mM and gK(ATP) = 0.0035 nS/pF), and subsequent application of TTX in primary L-cells. The average Ca2+ current is indicated by the red lines (right axis) D: As in panel C, except gCaT = 0.11 nS/pF. E: Simulation of current-evoked action potential in primary L-cells in control case (black line) and in presence of TTX (grey line). Black bar indicates the current application Iapp = 5 pA/pF. Grey bars indicate glucose and TTX application as indicated.