Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
Fig 5
Membrane currents during a single action potential.
A: Zoom on an action potential in GLUTag cells from Fig 1 with GSGLT1 = 1.5 mM. B: Membrane currents during the action potential in panel A. The currents have for clarity been divided according to their amplitude. Upper panel: ISGLT1 (blue), IK(ATP) (black), IKA (cyan), IK,hyper (green). Lower panel: INa (black), ICaHV A (red), IKv (blue). C: Zoom on an action potential in primary L-cells from Fig 4 with GSGLT1 = 1 mM. D: Membrane currents during the action potential in panel C. Upper panel: ISGLT1 (blue), IK(ATP) (black), ICaT (red). Lower panel: INa (black), ICaHV A (red), IKv (blue).