Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
Fig 3
Effect of stimulation with glucose at different concentrations (indicated by grey bars) on GLUTag electrical activity.
The stimulation with 1.5 mM glucose was simulated by changing extracellular SGLT1-substrate concentration, GSGLT1, from 0.1 mM to 1.5 mM, while gK(ATP) remained unchanged from its default value. Subsequent 20 mM glucose application was simulated by changing GSGLT1 from 1.5 mM to 20 mM, and gK(ATP) from 30 pS/pF to 25 pS/pF. A: Simulation of electrical activity triggered by different glucose concentrations. B: SGLT1-associated current corresponding to the simulation in panel A. C: K(ATP)-current corresponding to the simulation in panel A. D: Calcium current (blue) and its average (red) corresponding to the simulation in panel A.