Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
Fig 2
Model characterization of SGLT1-associated currents during voltage clamp as a function of SGLT1-substrate concentration, GSGLT1, and voltage pulse, Vpulse and parameters as for GLUTag model.
The voltage-clamp protocol consisted in applying 1 s depolarization at t = 0.5 s from a holding potential of -70 mV. A: Simulated SGLT1-associated current in response to different voltage pulses (Vpulse = −50, −30, −10, 10, 30 mV) and constant GSGLT1 = 5 mM. B: Simulated SGLT1-associated current in response to a voltage pulse (Vpulse = −10 mV) and different GSGLT1 = 0.1, 1, 5, 10, 20 mM. C: Simulated peak SGLT1-associated current in response to voltage pulses as a function of GSGLT1 and Vpulse. D: Simulated steady-state SGLT1-associated current in response to voltage pulses as a function of GSGLT1 and Vpulse.