Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
Fig 10
Syk activity in a hypothetical population.
The results of 200 simulations are shown (each simulation representing a hypothetical donor). Two markers of each simulation (peak Syk Y525 phosphorylation and time-to-peak) are denoted graphically by a circle. Two distinct populations are shown: a healthy population (green) where protein composition were varied across their normal range and a population with 75% deficiency in levels of GPVI. In all simulations parameter values are held fixed to those shown in Table J in S1 Text, set H3,1. The initial conditions of GPVI, Syk and c-Cbl are randomly selected from a range (healthy population: GPVI, +/-12%; Syk +/-22%, c-Cbl +/-25%; GPVI deficient population: GPVI, -25%+/-12%; Syk +/-22%, c-Cbl +/-25%) from the values given in Table D in S1 Text while TULA-2 is held steady to the value shown as there is no variation data for this protein. The large black circle indicates an individual with the mean protein levels that were obtained experimentally (GPVI, 5000; Syk, 2763; c-Cbl, 2581).