Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
Fig 9
Model predictions of the effect of ligand depletion (left) show close agreement to experimental data (right).
Model profiles of Syk activity are the result of a series of simulations where the ligand is decreased from 100% through to 1% of its original value. Experimental observations (right) are the result of a series of experiments where the agonist (CRP) is decreased from 100% through to 1% of its original value. Model profile (solid black line) utilises Model C (H3). Parameter values and initial conditions are taken from Tables J (parameter set H3,1) and D in S1 Text respectively.