Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
Fig 8
Model predictions for regulatory protein participation.
Simulations utilise the five best parameter sets (Table J in S1 Text) obtained from fitting the final model (i.e. Model C, H3) to experimental data: the variation in model predictions is low and all simulations predict that very few of the regulatory proteins, c-Cbl and TULA-2, are required to control Syk activity.