Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
Fig 4
Model A profiles compared to experimental observations of Syk phosphorylation on Y525.
Model profiles (black lines) compared to experimental observations (circles). The model accurately describes the steady state seen in experimental observations but is unable to describe the early peak in Syk Y525 phosphorylation. Experimental data of Syk phosphorylation (molecules per platelet) is the mean of three samples +/- S.E.M., phosphorylated (circles). Model simulations (solid lines) utilise parameter values from Table C in S1 Text (parameter set 1).