Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
Fig 3
A network diagram of Model A (top panel), B (middle panel) and C (lower panels).
Variables are represented by square boxes and the parameter associated with each processes is placed next to the relevant arrow. In all panels, from left to right, a ligand (l) binds to a free receptor (g) on the cell surface forming a receptor complex (G) that phosphorylates (Gp). In Model A Syk (s) binds to the receptor complex () and activates (
). The active receptor can then signal downstream. In the middle and lower panels, the components encased in the red box represent Syk phosphorylation on Y525 (equation S6) and those in the green box represent Syk phosphorylation on Y323 (equation S7). See Tables 1 and 2 for a description of the variables and parameters.