Towards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational Dynamics
Fig 2
Root mean square fluctuation analysis of TKs and Abl resistant mutants.
(a) RMSF of Abl and Src. Fluctuations of the N-lobe (left) and of the A-loop (right) for the Abl mutants (b). and the TKs (c). Shades of red and blue identify strong and weak binders, respectively. Dotted lines are used for clarity.