Fluctuation-Driven Neural Dynamics Reproduce Drosophila Locomotor Patterns
Fig 2
Locomotor patterns for genetically distinct Drosophila strains.
(A) Locomotor frequency for 98 strains from the Drosophila melanogaster Genetic Reference Panel (DGRP) during the odor impulse experiment. Strains are sorted by average pre-odor basal locomotor frequency. (B) The duration of locomotor decay following odor removal for all DGRP strains. Strains are ordered as in panel A. (C) The ratio of post-odor to pre-odor basal locomotion for all DGRP strains. Strains are ordered as in panel A. The black dashed line indicates no change in basal locomotion. Values below this line represent reduced post-odor basal locomotor frequency. (D) The basal locomotor frequency for 65 randomly sampled flies (50% of flies for the strain with the smallest sample size: 130 flies) from each strain. The mean (light gray boxes) and standard deviation (black error bars) of 100 random samplings for each strain are shown. Strains are ordered as in panel A. (E) The correlation (R2) between odor-evoked locomotion time-series for groups of 65 randomly sampled flies taken from either the same strain (red) or from different Drosophila strains (blue). Strains are ordered as in panel A. The mean of 100 correlation measurements is shown. (F) Walking trajectories (black lines) along the long axis of the arena during an odor aversion experiment for 201 flies of the DGRP strain 78 (RAL85). Red bars indicate the half of the arena filled with odor. A histogram of odor aversion values for these flies is shown below. For each fly, odor aversion was calculated as the time spent in the odor zone subtracted from the time spent in air zone, divided by the total time of the odor aversion experiment. The median for this population of flies is indicated (black arrowhead). (G) A scatter plot showing the correlation between mean pre-odor basal locomotion and median odor aversion across all 98 strains (Pearson’s correlation coefficient R = 0.65, P < 10−4). A black dashed line indicates the best linear fit.