An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States
Fig 9
Distinct differentiation propensities of the two intermediate states.
A, B, D, E) Stochastic simulations for a population of 5000 cells in four different conditions. Basal parameter set and intermediate external TGF-β concentration (0.5) were used (green star in Fig 6A). A) Initial condition: I1; small fluctuations. B) Initial condition: I1; large fluctuations. D) Initial condition: I2; small fluctuations. E) Initial condition: I2; large fluctuations. G, H) Stochastic simulations for a population of 5000 cells initially at I1 state. Ovol2 basal production level was reduced by 20% from basal parameter. J, K) Stochastic simulations for 5000 cells initially at I2 state. Ovol2 basal production level was increased by 100% from basal parameter. C, F, I, L) Metaphoric energy landscapes (green curves) for I1 (C), I2 (F) initial conditions, and reduced (I) or increased (L) Ovol2 basal expression rate. Orange circle represents the initial condition.