An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States
Fig 7
Roles of the Ovol2-Zeb1 mutual inhibition loop in the four-state EMT system.
Comparison of the basal model (left column), reduced Ovol2-Zeb1 mutual inhibition (middle column), and blocked Ovol2-Zeb1 mutual inhibition (right column) on the four phenotypes. Each subplot is a two-parameter bifurcation diagram similar to Fig 6A. Subplots in each column highlight the various phenotypes in one condition. Shaded areas are highlighted phenotypes. Colors of the shading correspond to the colored labels on the right.