Finding New Order in Biological Functions from the Network Structure of Gene Annotations
Fig 5
Functional Enrichment Analysis in Branches and Communities.
(A) A plot of the percentage of branches and percent of communities found to be enriched at p < 0.01 in each gene signature. Although both communities and GO-branches have enrichment in these signatures, many signatures are only enriched in communities and not branches at the p < 0.01 significance. We chose a subset of signatures to investigate further, and note those with a blue dot. (b) A heat map showing the statistical enrichment of selected cancer signatures (noted in (a) with a blue dot), as measured by AEA, in both GO branches and term communities.