Finding New Order in Biological Functions from the Network Structure of Gene Annotations
Fig 3
A Comparison of Branches in the GO DAG and Term Communities Found by Partitioning the Term Network.
(a) Distribution of Jm, the maximum similarity a community or branch with ten or more members has compared to all other branches or communities with ten or more members, respectively. Although a small number of communities and branches have similar memberships, most are highly dissimilar. (b)-(c) Two example comparisons between communities and branches: (b) TC:0003876 compared to GO:0015298, and (c) TC:0011556 compared to GO:0090559. In each panel on the left hand side a community and its inter-community connections in the annotation-driven term network is shown and on the right hand side the branch with which that community has the the highest Jaccard similarity is illustrated. In the right panel edges represent the ontological associations defined by the Gene Ontology term hierarchy. Each term member of the community or branch is colored both by its associated primary domain (inner color—BP:yellow, MF:cyan, CC:magenta) and its community membership (outer color), determined at the same resolution value as the illustrated community. Terms common between each community and branch pair are circled. To read term-labels, please zoom in.