Finding New Order in Biological Functions from the Network Structure of Gene Annotations
Fig 1
Visual Representation of Our Approach.
First, we summarize gene annotations made to functional terms in the Gene Ontology hierarchy as a gene-term bipartite graph. From these gene-term relationships, we project a term-term network. We partition this network into communities and compare those term communities to branches of terms in the DAG. Finally, we perform functional enrichment analysis on experimentally-defined gene sets using both the term communities and GO branches.