Relating Cortical Atrophy in Temporal Lobe Epilepsy with Graph Diffusion-Based Network Models
Fig 1
(a) TLE-MTS atrophy distribution. As expected, the hippocampus has the highest atrophy, consistent with TLE-MTS. (b) Pearson correlation R between Φ1 and measured atrophy vs. the number of eigen-modes used. Peak R is reached when eigen-modes u2–68 are used. (c) Atrophy distribution estimated using Model 1 using eigen-modes u2 − u68. Model 2: (d) Correlation R obtained when each node is seeded (model Φ2). The highest R is obtained when the hippocampus is seeded. (e) R vs. graph diffusion depth. Hippocampus seeding leads to the highest R is obtained at t = 5.56, followed by amygdala and the hypothalamus. (f) Estimated TLE-MTS atrophy obtained from Model 2 when the hippocampus is seeded.