Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features
Fig 6
Activation kinetics of peak retention controls the late response of the immediate early gene expression dynamics.
(A) First order sensitivity indices at each timepoint from 5 to 55 min for c-Fos mRNA. See Fig 3B for details. (B) High, Mid and Low c-Fos immediate gene expression (IEG) phenotypes at late phase of the dynamics as shown by red, green and blue colors, respectively. See Fig 5A for details. (C) The corresponding upstream signaling kinase profiles for FRK, ERK and JNK responsible for shaping the c-Fos IEG phenotypes displayed in B. (D) Decision tree displaying the combination rules of signaling features necessary to stratify the late c-Fos IEG downstream responses. See Fig 5C for details. (E) Plot of the only dominant signaling feature, τ2E, distinctively separating three c-Fos IEG phenotypes. (F) The corresponding downstream transcription factor profiles for Total AP-1, ppc-FOS:ppc-JUN and ppc-JUN:ppc-JUN shaped by c-Fos IEG phenotypes displayed in B. (G) First order sensitivity indices to c-Jun mRNA. (H) High, Mid and Low c-Jun IEG phenotypes at late phase of the dynamics (I) The corresponding upstream signaling kinase profiles for FRK, ERK and JNK responsible for shaping the c-Jun IEG phenotypes, displayed in H. (J) Decision tree displaying the combination rules of signaling features necessary to stratify the late c-Jun IEG. (K) Scatter plot of the first two dominant signaling features, τ2J and α1J distinctively separating three c-Jun IEG phenotypes, shown through dotted lines. (L) The corresponding downstream transcription factor profiles shaped by c-Jun IEG phenotypes, displayed in H.