Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features
Fig 3
Transcriptional regulatory activity is controlled by initial delay and activation kinetics of the signaling dynamics.
(A) Density plot for 100,000 simulation results at each time point from 0 to 60 minutes for transcription factors ppc-FOS:ppc-JUN, ppc-JUN:ppc-JUN and Total AP-1. (B) Variance based first order sensitivity coefficients (Si) of signaling features at each time point from 5 to 55 min as line plots to ppc-FOS:ppc-JUN, ppc-JUN:ppc-JUN and Total AP-1, respectively. The first and last five minutes of Si’s are not shown due to the expected instabilities in numerical estimation when dealing with near-zero values. Maximum Si at each timepoint is shown as the color bar on top of each line plots. Refer to Table 1 for details of the signaling feature symbols.