Establishing a Statistical Link between Network Oscillations and Neural Synchrony
Fig 7
Shared oscillations contribute to spike synchrony between hippocampal CA1 pyramidal cells in vitro.
(A, B) Reconstructed morphologies (left) and raster plots of spike trains (right) evoked in two CA1 pyramidal cells by an arbitrary stimulus waveform with a shared oscillatory signal (“Exp. 2”). Red circles show synchronized spikes between the two neurons. (C) Estimated phase modulation of the two recorded neurons in response to a shared oscillatory signal simulating a network-wide oscillation. (D) In the absence of a shared oscillatory signal, the simplified model (stimulus, or PSTH effects [P] + spike or auto-history effects [H]) lacking an oscillatory factor accurately predicts the observed number of synchronous spikes between the two neurons. (E,F) In the presence of a shared oscillatory signal, the simplified model (P + H) fails to explain the observed number of synchronous spikes (E) while the full model (stimulus, or PSTH effects [P] + spike or auto-history effects [H] + an oscillatory factor [O]) containing an oscillatory factor accurately predicts the observed number of synchronous spikes (F).