Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components
Fig 12
Influence of nuclei position on the behaviour of a cell layer under 40% compression.
a) Elevated nuclei position facilitates buckling. b) Nuclei positioned near the BM suppresses buckling. The BM and cell-cell adhesion parameters are given by = 1×10−11 N/m, δBM = 0.3 μm,
= 5x10-10 N/m, δM = 0.2 μm. The position of the nucleus at the base of the cell reduces the likelihood of buckling.