Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components
Fig 9
Influence of membrane and basement membrane spring constants on cell shapes in an epithelial layer.
In all cases the influence radii are δBM = 2μm and δM = 0.2μm. Increasing the adhesion to the basement membrane () leads to spread cells, while increasing adhesion between cells (
) leads to cells with a columnar appearance.