Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components
Fig 4
Influence of BM parameters on cell spreading.
The attraction of membrane particles to the BM is characterised by both a linear attractive force (adhesion) spring constant and an influence radius. These quantities correspond to, for example, the extension distance of filopodia to a surface and the force generated by the filopodia. The influence radius δBM has a greater influence on the geometry of the cell as compared to the spring constant .