Feed-Forward versus Feedback Inhibition in a Basic Olfactory Circuit
Fig 4
Network activity and response sparseness generated by different inhibitory motifs.
Colors indicate these motifs: no giant GABAergic neuron inhibition (noGGN) (green), feed-forward (FF) inhibition (blue), and feedback (FB) inhibition (red). (A) The average numbers of action potentials (APs) per trial for Kenyon cells (KCs). The average numbers of action potentials (APs) per trial for lateral horn neurons (LHNs). (B) The sparseness of odor representation across all Kenyon cells. (C) Frequency distribution of KC and LHN response intensity (total number of spikes elicited by a 1-s odor presentation) for different odor concentrations. (D) The number of cells generating an action potential in response to stimuli. Very high numbers of APs and unrealistically active KCs elicited by “high” odor concentrations suggest that the physiological range usually explored in vivo corresponds to “low-medium” range of the model.