Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks
Table 6
Gene expression classification in the MCF-7 estrogen response GRN using various selections of regulatory nodes based on their core numbers, K, in K-core hierarchy.
In the top half of the table the innermost core regulators (K ≤ 2) are always included and the cumulative effect of adding further core regulators is measured. In the bottom half of the table the innermost core regulators (K ≤ 2) are excluded in order to measure the individual contributions of regulators at various core levels. Classification accuracy is reported in terms of area under the ROC curve (AUROC) for real valued classifiers (LR, SVR and PCA) and Matthew’s correlation coefficient (MCC) for binary classifiers (SVC).