Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks
Fig 9
Hierarchical organization of all regulatory molecules, including 106TFs and 58miRNAs, in MCF-7 estrogen response GRN using K-core algorithm.
TF and miRNA nodes are represented by rectangles and diamonds respectively. Nodes are colored red or green depending upon whether the molecule’s expression is up or down-regulated in E2 vs. Control cells. The hierarchy is based on the principle of network centrality where nodes which are more important for the flow of regulatory information are more towards the core. Nodes in core 1 (Myc) are most central, followed by nodes in cores 2, 3, and so on in decreasing order of centrality. Some cores have been clubbed together for ease of visualization.