VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires
Fig 5
MS patient-derived repertoire is enriched for TCR sequences with long VJ insert, partially due to high abundance of specific Variable segment regions. A. Length of Variable and Joining segment germline parts within CDR3 (V-germ and J-germ) and of VJ insert (VJ-junc) compared between MS donors and healthy controls. B. Average length of VJ junctions among all and selected V-segments (TRBV5-6,5–1,5–8,7–6 and 20–1, shown to be over-expressed in MS patients compared to controls, see main text) according to TCR sequences from repertoires of healthy donors. C. Comparison of VJ insert lengths between control and MS donors for clonotypes with TRBV5-6,5–1,5–8,7–6 and 20–1 segments. P-values computed using two-tailed unpaired T-test (A, C) and paired T-test (B).