VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires
Fig 4
Analysis of autologous HSCT-driven changes in T-cell repertoire.
A. Stacked clonotype frequency plot highlighting the details of overlap between sample MS8 (before autologous HSCT) and MS8-HSCT (post HSCT). Top 100 clonotypes based on their average frequency in those samples are shown, while other clonotypes that were observed in both samples are marked as “Not shown”. The frequency of remaining clonotypes is marked as “Not in overlap”. B. Changes in Variable-Joining segment pairing in CDR3 junctions changes induced by HSCT. Chord diagram is used for visualization, ribbons connecting segment pairs are scaled by corresponding V-J pair frequency. “TRB” prefix is stripped from segment names for simplicity.