Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles
Fig 5
Breakdown of the performance of the interface profile score compared to other potentials for different classes of mutations.
Favorable: ΔΔG ≤ 0 kcal/mol, Strongly Favorable ≤ -1 kcal/mol, Unfavorable: ΔΔG ≥ 0 kcal/mol, Strongly Unfavorable: ΔΔG ≥ 0 kcal/mol, Neutral ΔΔG ≤ 1 kcal/mol and ≥ 1 kcal/mol. See text for a description of each potential.