Efficient Optimization of Stimuli for Model-Based Design of Experiments to Resolve Dynamical Uncertainty
Fig 4
An illustration of the optimal experimental design for the TCR example.
(a) Model simulation of the output dynamics of the measurable species under the optimal input provided in Table 6 simulated with ΩRA. The red dots specify the selected optimal measurement points by the mean values generated by nominal plant with additive 10% Gaussian noise. Error bars are also given by the standard deviation of the simulated data (three data points are generated for each time point). (b) The initial (grey) and final (blue) uncertainty in the target states dynamics. The designed experiment reduces the uncertainty region by 46%,99%,85% and 59% for free SHP, ZAP, ppMEK and ppERK, respectively. The red line shows the simulated dynamics of the nominal plant.