Efficient Optimization of Stimuli for Model-Based Design of Experiments to Resolve Dynamical Uncertainty
Fig 3
Supporting details of optimal experiment design for Hes1 example.
(a) The measurement scenario tree representation for selecting optimal measurements. Each node defines, the measurement pairs with the predicted value of the distinguishability metric, ξ, target dynamical uncertainty, γ, and three estimated measurement values from simulation, G1, G2, and G3. The path along the scenario tree with predictions closest to the data from the nominal plant is shown in red. (b) Reduction of TDU and (c) individual variance of target states with each additional unique measurement from the scenario tree.