A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle
Fig 5
Attractors recovered by simulations of loss- or gain-of-function mutants of four CC components.
(A) The simulation of loss of CDKB1;1 function produced only one cyclic attractor with period 7 that resembles G1 → S → G2 → G1 cycle, whereas in (B) with simulation of loss of KRP1 function, one cyclic attractor was attained, which has period 11 and comprises 100% of the initial conditions. This attractor is almost identical to WT phenotype but without KRP1. With the simulation of APC/C gain-of-function, a single attractor with period 7 was recovered, which is shown in (C) and is consistent with an endoreduplication cycle. Attractors obtained with the simulation of E2Fa overexpression are shown in (D). Two attractors were found, one of them has period 10 and the 40.48% of the initial conditions converge to that cycle that is closely similar to the WT CC attractor. The second attractor that correspond to E2Fa overexpression has period 8 and it is very similar to the endoreduplication attractor of loss of CDKB1;1 function, which comprises 59.52% of possible network configurations.