Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening
Fig 2
Enrichment plots of the ASCT2 models indicate the suitability of the models for productive virtual screening.
Enrichment plots of ASCT2 in (A) the occluded conformation, (B) the outward open conformation and (C) the outward open conformation with Asp460 facing the binding site. The enrichment plots are represented in red, whereas the plot that is expected by random selection of ligands is represented in a dashed blue line. The bottom panel shows the enrichment in a semi-logarithmic scale.