Modeling and Classification of Kinetic Patterns of Dynamic Metabolic Biomarkers in Physical Activity
Fig 1
The volcano plot displays the log2(MFC) between minimum and maximum concentrations values versus the-log10(P-value) calculated from statistical hypothesis testing. The horizontal blue line indicates the selected significance level of 0.001. The vertical blue line indicates the threshold for classification as moderate predictor (MFC > 1.20). The vertical green line denotes the classification threshold for a strong predictor (MFC > 1.40). Acetylcarnitine (C2), propionylcarnitine (C3) and alanine could be selected as strong biomarker candidates. Valerylcarnitine (C5), arginine, glucose, butyrylcarnitine (C4), methylmalonylcarnitine (C3-DC-M), and hydroxyvalerylcarnitine (C5-OH) were identified as moderate biomarker candidates.