Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data
Fig 11
Spheroids show a radial organization of cell phenotypes: proliferating (green), quiescent (blue) and dying cells (black).
The thickness of those layers is controlled by different factors as growth promoters (GP), growth inhibitors (GI), viability promoters (VP) and inhibitors (VI). The different control molecular components can largely be mapped on the control molecules emerging in our final model.