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Consistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence Annotation

Fig 8

True versus inferred parameters for all methods.

The difference between inferred and true values for exonuclease deletion lengths, N-region lengths, and mutation frequency for all available BCR annotation methods on a simulated sample of 30,000 sequences; more tightly peaked around zero is better. partis is shown both for single sequences (k = 1) and for a multi-HMM (k = 5), which performs simultaneous inference on five clonally related sequences.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1004409.g008