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Consistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence Annotation

Fig 6

Correct gene calls versus sequence mutation frequency, i.e. the number of sequences for which the specified method called the correct gene (regardless of allele) divided by the total number of sequences, versus sequence mutation frequency, for publicly-available BCR annotation methods on a simulated sample of 30,000 sequences.

partis is shown both for single sequences (k = 1), and for a multi-HMM (k = 5), which performs simultaneous inference on five clonally related sequences.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1004409.g006