Consistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence Annotation
Fig 1
The VDJ recombination process, in which individual V, D, and J genes are first randomly selected from a number of copies of each.
These genes are then joined together via a process that deletes some randomly distributed number of nucleotides on their boundaries then joins them together with random “non-templated” nucleotides in the N-region (blue). The specificity of an antibody is to a large extent determined by the region defined by the heavy chain recombination site, referred to as the third complementarity determining region (CDR3).