Informatics for RNA Sequencing: A Web Resource for Analysis on the Cloud
Fig 1
An overview of the central dogma of molecular biology.
The flow of genetic information from double-stranded genomic DNA template to post-translationally modified proteins is depicted with molecular features critical to each stage enumerated. RNA-seq typically targets the mature mRNA molecules. Abbreviations: donor splice site (D); acceptor splice site (A); polyadenylation (poly (A)); untranslated region (UTR); splice site (SS); exonic splicing enhancer (ESE), exonic splicing silencer (ESS), intronic splicing enhancer (ISE); intronic splicing silencer (ISS).