Dynamic Allostery of the Catabolite Activator Protein Revealed by Interatomic Forces
Fig 5
Allosteric network upon binding the second cAMP obtained from FDA.
Residue pairwise force differences between the cap1 and cap2 states are shown as blue sticks at (A) 50 pN and (B) 40 pN cut-off. (C) Zoom of B highlighting the allosteric connection pathway between the two protomers, which resembles pathway B in Fig 3D. (D) Zoom of B, highlighting the force changes in the Glu58-Arg87 and Glu58-Q174 pairs which connects the NBD with the DBD and which are symmetrically present in both protomers.