How Co-translational Folding of Multi-domain Protein Is Affected by Elongation Schedule: Molecular Simulations
Fig 1
A) Strucuture of SufI. N-, M-, and C-domains are depicted in blue, green, and red. Linkers that connet two domains are depicted in yellow. B) The codon-based elongation rate by Spencer et al’s algorithm. A threshold is introduced. The region where the elongation rate is slower than the threshold is drawn in red. C) The elongation schedule used in the CTFcodon simulations. Regions marked in red in B take long elongation time. D) Three CTF schems. The CTFfast (dashed), the CTFslow (dotted), and the CTFcodon (solid) lines. E) A schematic view of the system including the wall-and-tunnel potential.