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Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments

Fig 7

Deuterium enrichment in plasma glucose in one-day and seven-day D2-glucose labeling studies of humans.

The measured enrichment in plasma glucose in the one-day (grey circles) and seven-day (black diamonds) D2-glucose labeling studies. The end of the one-day and seven-day labeling periods are marked by a dashed grey line and a dotted black line respectively. Although subjects in the one-day labeling experiment (N = 8) received approximately twice as much deuterated glucose per day as subjects in the seven-day labeling study (N = 4), their median label enrichment is only slightly higher. Median plasma glucose enrichment in the one-day labeling study = 23%, median plasma glucose enrichment in the seven-day labeling study = 17%.

Fig 7

doi: https://doi.org/10.1371/journal.pcbi.1004355.g007