Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments
Fig 4
Enrichment curves of D2O labeled mice.
Best fits to the fraction of deuterium enrichment in plasma (A) and the percentage of label enrichment in the DNA of thymocytes (B), PBMC (C), and splenocytes (D) after seven-days of D2O labeling. Thymocytes were used to determine the maximum percentage of labeled DNA that cells could possibly attain (Methods), and all measured enrichments were scaled to this maximum. Dots represent individual mice. The end of label administration at day 7 is marked by a dashed vertical line.