Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models
Fig 7
PleC kinase conformation is required to establish replicative asymmetry.
Concentration gradients are color coded as in Fig 5. (A) In ΔpleC mutant cells (K-P-B-), free active form of DivL is lower than in wild-type cells, resulting in loss of CtrA~P in the predivisional cell. (B) In pleCH610A mutant cells (K-P-B+), an elevated level of DivK~P results in less active form of DivL and reduced CtrA~P. (C) In pleCF778L mutant cells (K-P+B+), inhibitor sequestration is retained, resulting in a normal CtrA~P gradient.